Automated Synthesis and Analysis Platform for Chemistry (ChemASAP)

KNMFi Laboratory for Automation and Data Management

ChemASAP is being established to support projects that require chemical entities such as organic or inorganic molecules (e.g., for incorporation into or onto materials). The ChemASAP platform offers various modules for the synthesis, purification, and analytical characterization of chemical compounds, which can be used either individually or in combination (https://www.chemasap.kit.edu/).

Until all modules are fully integrated, access to individual sub-areas (i.e., single ChemASAP modules) is provided by KNMFi. Once the platform is complete, automated processes for synthesis and analysis will be available as part of a fully integrated pipeline.

Scientists with in-depth expertise in chemistry and synthesis can use the platform by implementing their own protocols. Researchers without specialized expertise may apply for access to the platform and its capacities to design and plan experiments.

KIT

Functions and Technologies

Compound handling: Multiple complementary dosing systems enable the precise handling of solid, liquid, and gaseous chemicals, reactants, and solvents across a range from nanoliters to multi-milliliter volumes. Furthermore, chemicals and consumables can be stored in fully automated storage systems at room temperature or under refrigerated conditions.

Chemical synthesis: Thermal, photochemical and electrochemical reactors enable reactions to be conducted under a variety of controlled conditions. Integrated workup and purification systems allow for the efficient isolation of pure compounds from crude reaction mixtures.

Analysis and characterization: Chemical characterization is performed using a range of analytical instruments integrated into the platform.

KIT

Example of compund handling:
Analytical Sample Preparation

KIT

Example of chemical synthesis:
Supercritical fluid chromatography mass spectrometry for preparative compound purification

KIT

Example of analysis and characterization:
NMR Spectroscopy

Detailed List of Devices

Device Type: Description: Vendor: Model:
Compound handling Acoustic Liquid Handler (nano- & microliter) Beckman Coulter ECHO 650
Chemical Storage System (room temp. & refrigerated) KIT  
Incubator Thermo Scientific Cytomat 10 C
Inert Solvent Dosing System Zinsser Analytic Lissy
Liquid Reactant Dosing System Zinsser Analytic Lissy
Sample Preparation Robot CTC /  Axel Semrau PAL / Chronect Robotic
Solid Chemical Dosing System KIT  
Solid Dosing System Zinsser Analytic Lissy
Solvent Dosing System Zinsser Analytic Lissy
Chemical synthesis Electrochemical Reaction Station (Batch & Flow) KIT (ETOS)  
Photochemical Reaction Station KIT  
Preparative SFC-LC/MS (ELSD, PDA, ESI-MS, single quad.) Shimadzu Nexera / LCMS2020
Preparative LC/MS (ELSD, PDA, ESI-MS, single quad.) Shimadzu Nexera / LCMS2020
Solvent Evaporation Biotage V-10
Sublimation CreaPhys (MBRAUN) DSU05
Thermal Reaction Station KIT  
Analysis & characterization
Analytical LC/MS (ELSD, PDA, ESI-MS, single quad.) Shimadzu Nexera / LCMS2020
Analytical SFC-LC/MS (ELSD, PDA, ESI-MS, single quad.) Shimadzu Nexera / LCMS2020
Atmospheric RGA Mass Spectrometer MKS Cirrus 33
Fluorescence Spectrometer Hamamatsu FLS1000
GC-BID (Headspace sampling) Shimadzu Nexis GC-2030
GC-FID/MS (EI, single quad MS) Shimadzu Nexis GC-2030 / GCMS-QP2020 NX
Cyclovoltammetry KIT  
Nuclear Magnetic Resonance (NMR) Bruker Ascend 400
Polarimeter Anton Paar MCP 4100 SW
Surface Plasmon Resonance (SPR) Bruker SPR-24 Pro