Automated Synthesis and Analysis Platform for Chemistry (ChemASAP)
ChemASAP is being established to support projects that require chemical entities such as organic or inorganic molecules (e.g., for incorporation into or onto materials). The ChemASAP platform offers various modules for the synthesis, purification, and analytical characterization of chemical compounds, which can be used either individually or in combination (https://www.chemasap.kit.edu/).
Until all modules are fully integrated, access to individual sub-areas (i.e., single ChemASAP modules) is provided by KNMFi. Once the platform is complete, automated processes for synthesis and analysis will be available as part of a fully integrated pipeline.
Scientists with in-depth expertise in chemistry and synthesis can use the platform by implementing their own protocols. Researchers without specialized expertise may apply for access to the platform and its capacities to design and plan experiments.
Functions and Technologies
Compound handling: Multiple complementary dosing systems enable the precise handling of solid, liquid, and gaseous chemicals, reactants, and solvents across a range from nanoliters to multi-milliliter volumes. Furthermore, chemicals and consumables can be stored in fully automated storage systems at room temperature or under refrigerated conditions.
Chemical synthesis: Thermal, photochemical and electrochemical reactors enable reactions to be conducted under a variety of controlled conditions. Integrated workup and purification systems allow for the efficient isolation of pure compounds from crude reaction mixtures.
Analysis and characterization: Chemical characterization is performed using a range of analytical instruments integrated into the platform.

Example of chemical synthesis:
Supercritical fluid chromatography mass spectrometry for preparative compound purification
Detailed List of Devices
| Device Type: | Description: | Vendor: | Model: |
|---|---|---|---|
| Compound handling | Acoustic Liquid Handler (nano- & microliter) | Beckman Coulter | ECHO 650 |
| Chemical Storage System (room temp. & refrigerated) | KIT | ||
| Incubator | Thermo Scientific | Cytomat 10 C | |
| Inert Solvent Dosing System | Zinsser Analytic | Lissy | |
| Liquid Reactant Dosing System | Zinsser Analytic | Lissy | |
| Sample Preparation Robot | CTC / Axel Semrau | PAL / Chronect Robotic | |
| Solid Chemical Dosing System | KIT | ||
| Solid Dosing System | Zinsser Analytic | Lissy | |
| Solvent Dosing System | Zinsser Analytic | Lissy | |
| Chemical synthesis | Electrochemical Reaction Station (Batch & Flow) | KIT (ETOS) | |
| Photochemical Reaction Station | KIT | ||
| Preparative SFC-LC/MS (ELSD, PDA, ESI-MS, single quad.) | Shimadzu | Nexera / LCMS2020 | |
| Preparative LC/MS (ELSD, PDA, ESI-MS, single quad.) | Shimadzu | Nexera / LCMS2020 | |
| Solvent Evaporation | Biotage | V-10 | |
| Sublimation | CreaPhys (MBRAUN) | DSU05 | |
| Thermal Reaction Station | KIT | ||
| Analysis & characterization |
Analytical LC/MS (ELSD, PDA, ESI-MS, single quad.) | Shimadzu | Nexera / LCMS2020 |
| Analytical SFC-LC/MS (ELSD, PDA, ESI-MS, single quad.) | Shimadzu | Nexera / LCMS2020 | |
| Atmospheric RGA Mass Spectrometer | MKS | Cirrus 33 | |
| Fluorescence Spectrometer | Hamamatsu | FLS1000 | |
| GC-BID (Headspace sampling) | Shimadzu | Nexis GC-2030 | |
| GC-FID/MS (EI, single quad MS) | Shimadzu | Nexis GC-2030 / GCMS-QP2020 NX | |
| Cyclovoltammetry | KIT | ||
| Nuclear Magnetic Resonance (NMR) | Bruker | Ascend 400 | |
| Polarimeter | Anton Paar | MCP 4100 SW | |
| Surface Plasmon Resonance (SPR) | Bruker | SPR-24 Pro |



